Percutaneous epididymal sperm aspiration for men with obstructive azoospermia: Predictors of outcomes
Mohammad H Alkandari 3, Nawar Touma1, Armand Zini2.
1Faculty of Medicine, McGill University, Montreal, QC, Canada; 2Division of Urology, St-Mary's Hospital , Montreal, QC, Canada; 3Division of Urology, McGill University Health Center , Montreal, QC, Canada
Introduction: We sought to evaluate sperm retrieval and pregnancy outcomes following percutaneous epididymal sperm aspiration (PESA) and intra-cytoplasmic sperm injection (ICSI) in men with obstructive azoospermia (OA).
Methods: Data were collected retrospectively from 533 patients with OA who underwent PESA between March 2007 and June 2019. Sperm retrieval outcomes were reported as motile sperm (>1% motile), rare motile sperm (≤1% motile), non-motile sperm and no sperm found. We recorded clinical pregnancy per embryo transfer and live birth rates.
Results: Following PESA, motile sperm were detected in 404 patients (75.8%), rare motile sperm in 41 (7.7%), non-motile sperm in 67 (12.6%) and no sperm were found in 21 (3.9%). There was no difference between the groups in terms of paternal age, however, there was a significantly higher testicular volume in men who had motile sperm compared to those who had no sperm or nonmotile sperm (p=0.015). The overall clinical pregnancy and live birth rates per embryo transfer were 37.6% and 23.7%, respectively, with a mean of 1.1 (±0.5) embryos transferred. Paternal age, clinical diagnosis and sperm motility were not associated with clinical pregnancy rates.
Conclusions: The data suggest that PESA yields good motile sperm retrieval rates in patients with OA with overall good pregnancy rates. Larger testicular volume was predictive of higher motile sperm retrieval rates.
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||Unmoderated Posters||Percutaneous epididymal sperm aspiration for men with obstructive azoospermia: predictors of outcomes||TBD|