UP-73 The impact of surgery and stone passage on kidney stone patient quality of life
Thursday June 27, 2019 from
TBD
Presenter

Brendan BR Raizenne, Canada

University of Montreal

Abstract

The impact of surgery and stone passage on kidney stone patient quality of life

Brendan Raizenne1, Zhe Tian1, Kristina L. Penniston2, Seth K. Bechis3, Roger L. Sur3, Stephen Y. Nakada2, Jodi A. Antonelli4, Necole M. Streeper5, Sri Sivalingam6, Davis P. Viprakasit7, Timothy D. Averch8, Jaime Landman9, Thomas Chi10, Vernon M. Pais Jr11, Ben H. Chew12, Vincent G. Bird13, Naeem Bhojani1.

1Division of Urology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada; 2Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; 3Department of Urology, University of California San Diego, San Diego, CA, United States; 4Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, United States; 5Division of Urology, Pennsylvania State University College of Medicine, Hershey, PA, United States; 6Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, United States; 7Department of Urology, University of North Carolina School of Medicine, Chapel Hill, NC, United States; 8Department of Urology, Palmetto Health USC Medical Group, Columbia, SC, United States; 9University of California Irvine School of Medicine, Orange, CA, United States; 10Department of Urology, University of California San Francisco, San Francisco, CA, United States; 11Urology Section, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States; 12Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada; 13Department of Urology, University of Florida College of Medicine, Gainesville, FL, United States

Introduction: With a 5 year stone recurrence rate of 30-50%, kidney stone formers are subject to significant morbidity which negatively impacts their Health Related Quality Of Life (HRQOL). Spontaneous stone passage is associated with frequent emergency room visits, significant pain, and discomfort in performing daily activities. We sought to determine the impact of stone surgery and stone passage on patients’ individual HRQOL by querying the validated and prospectively collected Wisconsin Stone Quality of Life (WISQOL) database.

Methods: Cross-sectional data was obtained from a total of 3207 kidney stone formers from 14 institutions in North America who completed the WISQOL questionnaire from 2014 to 2019. The 28 question survey has a 1-5 point scale for each item (total score range 0-140) and is divided into 4 domains: D1 social functioning, D2 emotional functioning, D3 stone-related impact, and D4 vitality. Univariable and Multivariable linear regression models were used to assess the impact of time since most recent surgery and time since most recent stone passage on HRQOL.

Results: Of the 1,376 kidney stone formers who had surgery between 2010-2019, time since most recent surgery was an independent predictor of better WISQOL scores in univariable and multivariable analysis (β = 2.55 points/year; CI: 1.67-3.42; p=<0.001 and β = 2.26 points/year; CI: 1.44-3.08; p=<0.001) (Table 1). Of the 1,027 kidney stone formers with stone passage between 2010-2019, time since most recent stone passage was an independent predictor of better WISQOL scores in univariable and multivariable analysis (β = 2.51 points/year; CI: 1.47-3.55; p=<0.001 and β = 1.59 points/year; CI: 0.59-2.59; p=<0.05) (Table 2).  We performed a subgroup analysis with 626 kidney stone formers with surgery and stone passage between 2010-2019. Time since most recent event (surgery or stone passage) was an independent predictor of better WISQOL scores in univariable and multivariable analysis (β=5.58 points/year; CI: 3.74-7.43; p<0.001 and β = 3.75 points/year; CI: 1.97-5.53; p<0.001) (Table 3).

Conclusion: Our study demonstrates that increased time from most recent surgery and increased time from most recent stone passage were independent predictors associated with better HRQOL in kidney stone formers. Further studies should focus on optimizing stone related modifiable risk factors to decrease the amount of recurrent stone episodes.


Lectures by Brendan BR Raizenne


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